Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker LHGDN Annexin A2 positively contributes to the malignant phenotype and secretion of IL-6 in DU145 prostate cancer cells. 18924133

2009

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker LHGDN p38MAPK activation is involved in androgen-independent proliferation of human prostate cancer cells by regulating IL-6 secretion. 17196171

2007

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker LHGDN Interleukin-6 undergoes transition from growth inhibitor associated with neuroendocrine differentiation to stimulator accompanied by androgen receptor activation during LNCaP prostate cancer cell progression. 17373716

2007

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker LHGDN Interleukin-6 activates PI3K/Akt pathway and regulates cyclin A1 to promote prostate cancer cell survival. 18027847

2008

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker LHGDN The Fer tyrosine kinase cooperates with interleukin-6 to activate signal transducer and activator of transcription 3 and promote human prostate cancer cell growth. 19147545

2009

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 GeneticVariation LHGDN Interleukin-6 polymorphism is associated with more aggressive prostate cancer. 16006970

2005

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 AlteredExpression LHGDN Constitutive activation of nuclear factor kappaB p50/p65 and Fra-1 and JunD is essential for deregulated interleukin 6 expression in prostate cancer. 12727841

2003

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 AlteredExpression LHGDN Synergism of cytoplasmic kinases in IL6-induced ligand-independent activation of androgen receptor in prostate cancer cells. 14981536

2004

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker LHGDN Interleukin-6 is an autocrine growth factor in human prostate cancer. 11733366

2001

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 AlteredExpression LHGDN Depletion of intracellular zinc increases expression of tumorigenic cytokines VEGF, IL-6 and IL-8 in prostate cancer cells via NF-kappaB-dependent pathway. 18615482

2008

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker LHGDN Interleukin-6 regulates androgen receptor activity and prostate cancer cell growth. 12431817

2002

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 AlteredExpression LHGDN Hepatocyte growth factor and interleukin-6 in combination with prostate volume are possible prostate cancer tumor markers in patients with gray-zone PSA levels. 17876341

2008

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker CTD_human Osteoblasts induce prostate cancer proliferation and PSA expression through interleukin-6-mediated activation of the androgen receptor. 15672864

2004

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker CTD_human p38MAPK activation is involved in androgen-independent proliferation of human prostate cancer cells by regulating IL-6 secretion. 17196171

2007

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Therapeutic CTD_human Niclosamide suppresses cell migration and invasion in enzalutamide resistant prostate cancer cells via Stat3-AR axis inhibition. 25970160

2015

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Therapeutic CTD_human Interleukin-6 stimulation of growth of prostate cancer in vitro and in vivo through activation of the androgen receptor. 19011039

2009

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Therapeutic CTD_human Interleukin-6 increases prostate cancer cells resistance to bicalutamide via TIF2. 19240160

2009

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker CTD_human Niclosamide suppresses cell migration and invasion in enzalutamide resistant prostate cancer cells via Stat3-AR axis inhibition. 25970160

2015

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker CTD_human Interleukin-6 stimulation of growth of prostate cancer in vitro and in vivo through activation of the androgen receptor. 19011039

2009

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Therapeutic CTD_human p38MAPK activation is involved in androgen-independent proliferation of human prostate cancer cells by regulating IL-6 secretion. 17196171

2007

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker CTD_human Interleukin-6 increases prostate cancer cells resistance to bicalutamide via TIF2. 19240160

2009

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Therapeutic CTD_human Osteoblasts induce prostate cancer proliferation and PSA expression through interleukin-6-mediated activation of the androgen receptor. 15672864

2004

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 AlteredExpression BEFREE Serum IL-6 levels also correlate with prostate tumor burden, prostate-specific antigen levels and metastasis. 24446297

2014

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 AlteredExpression BEFREE Immunohistochemistry studies showed increased levels of STAT3 and IL-6, but low levels of programmed cell death protein 4 (PDCD4), in prostate tumor epithelial cells compared to adjacent perinormal prostate epithelial cells. 28467474

2017

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 AlteredExpression BEFREE ESE3/EHF and IL-6 were significantly inversely correlated in prostate tumors. 27732936

2016